5-Amino-1MQ: A Premium NNMT Inhibitor for Metabolic Research

5-Amino-1MQ is a groundbreaking small molecule and NNMT inhibitor designed for advanced metabolic research . It functions by selectively inhibiting the enzyme Nicotinamide N-methyltransferase (NNMT), effectively breaking the cycle of metabolic slowdown linked to fat accumulation and supporting energy expenditure . This membrane-permeable compound works at the cellular level to increase NAD+ concentrations and activate sirtuins, making it a highly sought-after research peptide for metabolic and weight management studies .

Key Factual Details

• Chemical Name: 5-Amino-1-methylquinolinium iodide (NNMTi) .

• Chemical Formula: C₁₀H₁₁IN₂·H₂O (monohydrate salt form) .

• Molecular Weight: 159.21 g/mol .

• CAS Number: 42464-96-0 .

• Purity: Up to 99% (HPLC tested) .

• Mechanism: Potent NNMT inhibitor (IC50 = 1.2 μM), increasing NAD+ levels and enhancing cellular energy expenditure without stimulating the central nervous system .

• Key Mechanism: Binds selectively to NNMT's substrate-binding site, helping prevent adipogenesis and promote muscle stem cell regeneration .

• Administration: Subcutaneous injection is common in research settings .

Research Dosing

Dosing in research models is highly protocol-specific and not intended for human use. Typical ranges noted in preclinical studies:

• Typical Research Dosage: 50 mg to 150 mg per day in cycling protocols (e.g., 4-8 weeks on, 2-4 weeks off) .

• Oral Bioavailability: Demonstrates high oral absorption and bioavailability in research models .